Growth Differentiation Factor 15 as a Novel Biomarker for Metformin
نویسندگان
چکیده
منابع مشابه
Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders
OBJECTIVE The diagnosis of mitochondrial disorders (MDs) is occasionally difficult because patients often present with solitary, or a combination of, symptoms caused by each organ insufficiency, which may be the result of respiratory chain enzyme deficiency. Growth differentiation factor 15 (GDF-15) has been reported to be elevated in serum of patients with MDs. In this study, we investigated w...
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BACKGROUND Growth differentiation factor-15 (GDF-15), a stress-responsive transforming growth factor-ß-related cytokine, is elevated and independently related to an adverse prognosis in systolic heart failure. OBJECTIVE This study aimed to investigate plasma levels of GDF-15 in patients with preclinical diastolic dysfunction or heart failure with normal ejection fraction (HFnEF). METHODS We...
متن کاملGrowth differentiation factor‐15 as a prognostic biomarker in cancer patients
Growth differentiation factor-15 (GDF15) is a member of the transforming growth factor beta superfamily and has been demonstrated to play multiple roles in various pathological conditions such as cancer, inflammatory diseases, cardiovascular diseases, and metabolic disorders. Furthermore, recent studies have shown that plasma levels of GDF15 increased in patients with chronic diseases described...
متن کاملThe novel biomarker growth differentiation factor 15 in heart failure with normal ejection fraction
AIMS Heart failure with normal ejection fraction (HFnEF) is an important clinical entity that remains incompletely understood. The novel biomarker growth differentiation factor 15 (GDF-15) is elevated in systolic heart failure (HFrEF) and is predictive of an adverse outcome. We investigated the clinical relevance of GDF-15 plasma levels in HFnEF. METHODS AND RESULTS A subgroup of patients fro...
متن کاملGDF 15 ( growth differentiation factor 15 )
The premature GDF/PDF/MIC-1 protein consists of 308 amino acids that contain a 29 amino acid signal peptide, a 167 amino acid propeptide, and a 112 amino acid mature protein. The mature protein is secreted as a homodimer linked by disulfide bonds and is released from the propeptide following intracellular cleavage at RXXR furine-like cleavage site. The mature peptide of GDF-1/MIC-1 contains two...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2016
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc16-1682